i have a external hdd enclosure, can i put the hard drive i plan on using inside the enclosure then use superduper. then remove the hard drive from the enclosure and pop it right in the macbook with no problems booting from it?

You shouldn't have any problems as long as your going from the same type of computer(Macbook Pro to Macbook Pro) I had some problems once because i installed Snow leopard onto my mac pro from my macbook pro via firewire and i think it messed with drivers or something because the superdrives on my mac pro act funny sometimes when writing. Also make sure you make a carbon copy of the drive and not just drag and drop everything onto the new drive. I use Carbon Copy Cloner. Hope this helps.