I recently sim unlocked my iPhone using the process provided on this site, however it was before the GUI version was released. The process went fine but to get it working correclty I had to copy over the lockdown patch.

Now I need to restore my iPhone (got a bit happy with app install and its gone a bit wrong).

Can I restore in iTunes 7.4.1 on OS 10 and then simply use iNdependence 1.2.1 to activate and jailbreak without it screwing my sim unlock hack?

Also does it matter that I have used the lockdown patch and will this cause an issue at all?

Any advise would be great. Many thanks in advance.

You can restore it and you wont have to unlock the iphone again, just jailbreak and activate. You shouldn't have to do the lockdown patch again.